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SS-31
SS-31 (elamipretide) is a mitochondria-targeted tetrapeptide that selectively binds to cardiolipin in the inner mitochondrial membrane. It stabilizes electron transport chain complexes, reduces the production of reactive oxygen species, and enhances ATP synthesis. This peptide has demonstrated protective effects in preclinical models of heart failure, neurodegenerative diseases, and age-related muscle atrophy, and it received accelerated approval from the FDA in 2025.
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